A train carrying 139 passengers has collided with a freight train in the US state of South Carolina, killing two people, local police say.
The train’s lead engine and several passenger carriages derailed in the crash, Amtrak said in a statement.
Eight staff members were also on board the train, which was operating between New York and Miami.
It comes four days after a lorry driver was killed when his vehicle hit a train carrying lawmakers in Virginia.
The local sheriff department said more than 50 people were injured in the crash, which happened early on Sunday.
The American Red Cross says it has sent rescue workers to the scene of the crash in the city of Cayce.
There have been a number of fatal train crashes in recent years. Last December, three people were killed when a passenger train derailed after hitting a 30mph (50km/h) curve at 80mph in Washington state.